描述
化學性質
化學式 ：C15H10O5
分子量 ：270.24
熔 點 ：ca 315° dec.
Storage & Sensitivity ：Keep Cold.
可溶性：
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).
應用
4′,5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
注釋
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.
参考文獻
Hirano T.; Oka K.; Akiba M. Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Research Communications in Chemical Pathology and Pharmacology. 1989, 64 (1), 69-78.
Sunanda Panda.; Anand Kar. Apigenin (4,5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. Journal of Pharmacy and Pharmacology. 2007, 59 (11), 1543-1548.
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